OWL-PCOS Study Weight Loss Protocol
The OWL-PCOS study provided physicians with a detailed weight-loss strategy to share with their patients.1Patients are instructed to take the following action:
- Orlistat: (available OTC under the brand name Alli) to be taken as recommended + meal replacements contributing to a hypocaloric diet (~1200kcal/d) + lifestyle modification. To ensure adequate vitamin effects, take a vitamin supplement once a day, at least two hours before or after Orlistat. Institute Orlistat at a dose of 60 mg to be taken three times a day with meals. The dose may be skipped if the patient anticipates eating a high-fat meal to avoid the occurrence of unwelcome gastrointestinal side-effects.
- Meal Replacements：遵循每日饮食计划，持续16周，其中包括三个准备早餐，午餐和晚餐的准备主菜。此外，指示患者每天食用两份水果，三份蔬菜和两份脱脂牛奶。该饮食将提供约1,100卡路里的卡路里，具有大量营养素的特征：蛋白质的30％卡路里；碳水化合物的卡路里45％；和脂肪的25％卡路里。为了防止在高脂载荷服用Orlistat时可能发生的胃肠道副作用，每餐的总脂肪总量不得超过15克。应该鼓励患者使用SmartOnesmeal replacement products, which contain fewer than 10g of fat per meal (average is about 4g per meal). Similar brands that follow these guidelines areHealthy ChoiceandLean Cuisine. The addition of the required vegetable, fruit and low-fat dairy servings daily ensures that patients maintain a well-balanced low-fat, low-calorie nutritious diet with minimal side-effects.
- Lifestyle Modification:例cise or be physically active for approximately 150 minutes a week. Tailor physical activity to individual desires and abilities (acknowledging that some patients may be restricted by orthopaedic issues). Patients should chart the type and duration of exercise in daily exercise logs. All patients should be instructed to engage in moderately intense physical activity (principally brisk walking or similar aerobic activity) five days per week. Activity goals will begin at 10 minutes on each of those five days and gradually increase over four months to 30-35 minutes, for a total activity goal of 150 minutes per week.
Richard S. Legro, MD, FACOG
Professor, Vice Chair of Research, Reproductive Endocrinology
PHONE:717-531-8478
EMAIL:rlegro@PennStateHealth.psu.edu
奖学金:Reproductive endocrinology, University of Southern California – Berkley/Keck School of Medicine, Los Angeles, Calif.
RESIDENCY:Obstetrics and gynecology, Magee-Women’s Hospital, University of Pittsburgh, Pittsburgh, Pa.
MEDICAL SCHOOL:Icahn School of Medicine at Mount Sinai, New York, N.Y.
Connect with Richard S. Legro, MD, on Doximity
Reference:
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- Legro RS, Dodson WC, Kunselman AR, Stetter CM, Kris-Etherton PM, Williams NI et al.Benefit of delayed fertility therapy with preconception weight loss over immediate therapy in obese women with PCOS.J Clin Endocrinol Metab;2016年3月15日：1-9。