武装你的身体去战斗癌症
We’re committed to fighting cancer for you, and part of our commitment is bringing the latest, most promising treatments to central Pennsylvania - bringing hope closer to home. One example is CAR-T cell therapy, using your body’s own cells to fight cancer.
什么是Car-T细胞疗法？
嵌合抗原受体T细胞（汽车T）治疗是一种免疫疗法。这是一种使用身体自己的T细胞的基因治疗 - 某些白细胞通常称为免疫系统的“职脉” - 以攻击癌细胞。
美国食品和药物管理局（FDA）已批准批准的Car-T细胞疗法治疗某些类型的非霍奇金淋巴瘤和白血病，这些淋巴瘤和白血病尚未应对其他类型的治疗。FDA基于临床试验的阳性结果的批准，许多患者应对治疗，甚至实现完全缓解。
它是如何工作的？
Blood is taken from a vein in your arm through an intravenous line (IV). It flows through a tube to a machine that removes certain cells and sends the rest of the blood back into your body. This process can take a few hours, and you can usually go home afterward.
您的T细胞与其他细胞分离并送到实验室，在那里遗传修饰，以在其表面上产生微小的分子。受体使得T细胞能够识别癌细胞上的特定蛋白质或抗原。汽车-T细胞在实验室中繁殖，直到它们在数百万内的数量。在实验室中准备您的T细胞可能需要几周。
Before you receive your specially treated T cells, you will need three days of low-dose chemotherapy to prepare your body. Then the cells will be infused into your body through an IV. This one-time process takes about 30 minutes.
在你的身体中，Car-T细胞再现和攻击癌细胞。虽然你的身体在响应时，你可能感觉不舒服。你可能会在医院住了几天。离开后，您仍然需要在接下来的四周左右密切监视。我们的团队将跟踪治疗的工作程度如何，帮助您处理任何副作用。
对我有权吗？
Currently, CAR-T cell therapy is FDA-approved only for patients with certain kinds of non-Hodgkin’s lymphoma or leukemia, and only for those patients who have been through at least two other approved treatments. At Penn State Cancer Institute, we’re using it to treat certain kinds of lymphoma in adults. If you’ve been treated at least twice, and your lymphoma either did not respond or relapsed, you may qualify for this treatment.
可以用Car-T细胞疗法治疗的淋巴瘤的类型包括：
- Diffuse large B-cell lymphoma (DLBCL)
- 原发性纵隔大B细胞淋巴瘤
- 高级B细胞淋巴瘤
- DLBCL由卵泡淋巴瘤引起的
对于原发性中枢神经系统淋巴瘤不批准CAR-T细胞疗法。
Penn State Cancer Institute is the only hospital in central Pennsylvania that offers CAR-T cell therapy, a powerful, new treatment that harnesses the power of the immune system to fight cancer. Here’s a look at how CAR-T therapy works.
常见问题解答
我想我可能有资格获得Car-T细胞疗法。我该怎么办？
与您的医生讨论宾夕法尼亚州癌症研究所的转诊或致电833-531购物车（2278）。
What happens next?
我们将与您讨论谈论治疗，以后如何以及如何照顾自己。我们将进行评估，并询问您有关您的医疗和家族史的问题，您已经采取的任何药物和其他因素。如果我们同意您有资格获得并可从Car-T细胞疗法中受益，我们将创建治疗计划并开始调度约会。
Car-T细胞疗法的副作用是什么？
与其他癌症治疗一样，Car-T细胞疗法可具有严重的副作用，包括：
- High fever
- 极度疲劳
- 低血压
- Fast heartbeat
- Confusion
- 难以说话或剧本
您也可能具有更高的感染风险，低血细胞计数和其他并发症。这就是为什么保持所有后续约会尤为重要，并让您的医疗团队知道您可能拥有的任何症状。
治疗后我能期待什么？
你可能会住院数days after your infusion of CAR-T cells. Then you’ll need to stay near the hospital for about four weeks so you can come in for monitoring and treatment of side effects. You’ll need to refrain from driving for several weeks.
好消息：许多临床试验患者具有阳性结果。近40％的淋巴瘤患者取得了完全缓解，这意味着试验显示没有癌症的迹象。大约一半没有回应。没有人可以肯定在特定情况下是否可以在特定情况下工作，或者你是否会再次有淋巴瘤或其他一些癌症。研究仍然是为了更好地确定哪些患者会响应治疗，并评估和管理长期影响和副作用。
Will insurance cover CAR-T cell therapy?
大多数保险公司将根据具体情况下涵盖。Medicare和Medicaid将在某些情况下覆盖它。在我们开始之前，我们将与您讨论财务。
Will this therapy be used to treat other kinds of cancer?
Research is ongoing and promising. CAR-T cell therapy for other types of cancer is being tested in clinical trials. Also, CAR-T cell therapy is a type of immunotherapy, and other types of immunotherapy are being studied to treat cancer and other diseases. Penn State Cancer Institute is committed to this search for answers and new knowledge.
如何了解有关Car-T细胞疗法的更多信息？
Learn more about CAR-T cell therapy, how it works and what to expect in this教育视频。You can also call833-531购物车（2278）。
Follow Tim Card’s journey to remission as the Mount Joy resident becomes the first patient at Penn State Cancer Institute to receive CAR-T therapy.